Psalm 2:1 asks: “Why are the nations in an uproar, and the peoples devising a vain thing?”
The Psalmist here asks “WHY” the nations are in rebellion against God, when the last word of :1 (in Hebrew, the word “riq”) means “void, empty, vain, in vain.” Why are they doing what has no possibility of succeeding? They cannot “win” vs. God!

But numbers of us today might do well to ask ourselves the same question: why do we attempt to “skirt” around what God has ordained, when we have no possibility of succeeding in those attempts?

— you cannot commit adultery or dabble with pornography and somehow “get away” with it.
— you can’t otherwise compromise yourself financially or ethically and “win.”
— you can’t get in an “uproar” about something God has said in His word that you “don’t agree with”: whether it is the complementary role of women, or homosexuality, or any number of other issues. You are all in an uproar about something which will only be “in vain.” You cannot change what God has ordained in His created order.

Psalm 2 famously adjures those rebellious nations to submit themselves to God by “kissing the Son” (:12) and acquiescing to His Lordship and dominion. Many of us, even as professing Christians, need to do the same thing on any number of issues. Don’t “devise a vain thing” morally, or remain “in an uproar” over some issue in the Bible you disagree with. Fighting God is a battle you can’t win.